I find his comments worrying. They're vague enough that I hope my interpretations are wrong, as all I'm reading out of it is potential nerfs:
Karma should duo, She should compete with Sona, Mantras should feel ult.
That sounds like they want to force her into a more typical support role, probably giving her bad scaling in exchange for some increased base ability strength. She'll cease to be that amazing support for mêlée champions and become more bland and generic.
The part about Mantra feeling like an ult implies that they're thinking of making it an actual ult (only available at level 6, etc.) instead of how it works now, though hopefully not.
I think the biggest thing Karma players may miss is being able to target beam on enemies.
Spirit Bond no longer being able to target enemies makes it less useful than it is right now, despite it being the spell most people complain about. It also removes some of the unique "duality of purpose" which she has on all her spells.
I personally like
Spirit Bond because it's a hard spell to use properly that can have a major effect on fights with damage, slow and speed.
Hopefully I'm interpreting all of this the wrong way, though.