I disagree with you all.
I start with
2 x Armour Pen Quints
1 x Mana Regen Quint
7 x Attack Damage Reds
3 x Armour Pen Red
9 x HP Regen Yellow
9 x Mana Regen Blue
To give the starting stats (without masteries, 10-1-19 btw).
+6.6 Physical damage
+10.0 Armour pen
This build works best in mid.
Start with boots + 3 hp pots
With the cooldows from utility mastery and your mana regen + hp regen, you can harass like mad, and have amazing lane sustainability.
Every 10 seconds you can dash in and blind your enemy and get a couple of shots for free. To start with your opponent will be confident and wonder if your lv 5 or something, as you seem weak, but youll whittle them down as they will not be able to keep up with your regen, and blinding shot does massive damage when you can fire it off so liberally.
Unless your against a vlad or an alistar then your opponent will always have to back first, or youll kill them. its easy to kill them with ghost and your w.
Using this build i havnt lost a mid against anyone.
a few games ago i got 28-10 using this build, but i started trolling after about 25-2 so it could have been alot better.